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KMID : 0895419970070010061
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Journal of Korean Society of Occupational and Enviromental Hygiene
1997 Volume.7 No. 1 p.61 ~ p.69
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Effect of CCl4 - induced liver damage on the metabolism of toluene in rats
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Abstract
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To evaluate an effect of pathological liver damage on the toluene metabolism, the rate were induced acute liver damage with 3 times CCl₄ injection (0.1 ㎖ of 50 % in olive oil/100 g body wt.) three days. In the present animal molel, the injection of toluene(0.3 ㎖ of 50 % in olive ail) showed the more decreased urine hippuric acid throughout 24 hr in the liver damage induced animals(CCl₄-pretreated rats) than normal group. The activities of hepatic aniline hydraxylase, benzylalcohol dehydrogenase and henzaldehyde dehydrogenase were significantly decreased in CCl₄-pretreated rats than the normal group at 24 hr after injection of toluene.
Furthermore, the benzaldehyde dehydrogenase in poled liver of CCl₄-pretreated rats showed similar K_m value, but showed the mare decreased V_(max) value compared with the normal group by the injection ion of toluene.
These results suggest that the rats induced liver damage with CCl₄ tray reduce the toluene metabolism.
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